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Diagnosis and management of heparin-induced thrombocytopenia: third edition
Br. j. haematol ; 204(2): 459-475, 20240201.
Article in En | BIGG | ID: biblio-1537647
Responsible library: BR1.1
ABSTRACT
This guideline updates and widens the scope of the previ-ous British Society for Haematology (BSH) Clinical guide-lines for Diagnosis and Management of Heparin-Induced Thrombocytopenia Second Edition1 to include functional assays in the diagnosis of heparin-induced thrombocytope-nia (HIT), when to use direct-acting oral anti-coagulants, and the role of intravenous (IV) immunoglobulins and plasma exchange in the management of HIT and spontane-ous HIT.HIT is an immune-mediated, highly pro-thrombotic dis-order of platelet activation caused by pathogenic antibodies against a platelet factor 4 (PF4)­heparin complex. It is the most frequent drug-induced immune thrombocytopenia and may lead to life-threatening thrombosis. There are two distinct forms of HIT type I, also known as heparin-asso-ciated thrombocytopenia, which is a non-immunological response to heparin treatment, mediated by a direct interac-tion between heparin and circulating platelets causing plate-let clumping or sequestration, and type II, which is immune mediated.
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Full text: 1 Collection: 05-specialized Database: BIGG Main subject: Thrombocytopenia / Blood Platelets Language: En Journal: Br. j. haematol Year: 2024 Document type: Article

Full text: 1 Collection: 05-specialized Database: BIGG Main subject: Thrombocytopenia / Blood Platelets Language: En Journal: Br. j. haematol Year: 2024 Document type: Article